Dr. Yoon is honored with election into ASCI

   

Monthly Archives: April 2013

Han et al., Diabetes Metab J, 2013

Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterized by reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic factors. Previous studies have tried to introduce neurotrophic or angiogenic factors in the form of protein or gene for therapy, but the effect was not significant. Recent studies have shown that bone marrow (BM)-derived stem or progenitor cells have favorable effects on the repair of cardiovascular diseases.

Read More 

Boopathy et al., Stem Cell Res Ther, 2013

Oxidative stress-induced Notch1 signaling promotes cardiogenic gene expression in mesenchymal stem cells.

Read More 

4/22/13 Journal Club, Jaeyeaon Cho; Nam et al., PNAS, 2013

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5588-93. doi: 10.1073/pnas.1301019110. Epub 2013 Mar 4.   Reprogramming of human fibroblasts toward a cardiac fate. Nam YJ, Song K, Luo X, Daniel E, Lambeth K, West K, Hill JA, Dimaio JM, Baker LA, Bassel-Duby R, Olson EN. Departments of Molecular Biology, Internal Medicine, Cardiothoracic Surgery, and Urology, and Center for Human Genetics/McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390. […]

Read More 

Min Young Sin, awarded with SIRE grant program for summer 2013.

Another Yoon lab undergraduate volunteer, Min Young Sin, received Scholarly Inquiry and Research at Emory (SIRE) grant program for summer 2013. Min Young is currently a senior at Emory University and has been working at Yoon lab since her first year of college while planning to enter medical school. In addition, Min Young’s research proposal, […]

Read More 

Technology and innovation awardees for 2012

The 7th annual Celebration of Technology and Innovation in March honored the following awardees: Innovation of 2012: Chemically-induced pluripotent stem cells (Young-sup Yoon, cardiology) Start-up of 2012: Clearside Biomedical (Henry Edelhauser, ophthalmology). Last month, Clearside received $7.9 million in venture capital. Read more. Deal of 2012: Neurotrak’s licensing of its web-based diagnostic for Alzheimer’s (Stuart […]

Read More 

4/8/13 Journal Club, Kyuwon Cho, Boon et al., Nature, 2013

Ageing is the predominant risk factor for cardiovascular diseases and contributes to a significantly worse outcome in patients with acute myocardial infarction. MicroRNAs (miRNAs) have emerged as crucial regulators of cardiovascular function and some miRNAs have key roles in ageing. We propose that altered expression of miRNAs in the heart during ageing contributes to the age-dependent decline in cardiac function. Here we show that miR-34a is induced in the ageing heart and that in vivo silencing or genetic deletion of miR-34a reduces age-associated cardiomyocyte cell death. Moreover, miR-34a inhibition

Read More 

Sohn et al., Biomaterials, 2013

Since the successful generation of induced pluripotent stem cells (iPSC) from adult somatic cells using integrating-viral methods, various methods have been tried for iPSC generation using non-viral and non-integrating technique for clinical applications. Recently, various non-viral approaches such as protein, mRNA, microRNA, and small molecule transduction were developed to avoid genomic integration and generate stem cell-like cells from mouse and human fibroblasts. Despite these successes, there has been no successful generation of iPSC from bone marrow (BM)-derived hematopoietic cells derived using

Read More 

Andukuri et al., Tissue Eng Part C Methods, 2013

Endothelial progenitor cell (EPC)-capturing techniques have led to revolutionary strategies that can improve the performance of cardiovascular implant devices and engineered tissues by enhancing re-endothelialization and angiogenesis. However, these strategies are limited by controversies regarding the phenotypic identities of EPCs as well as their inability to target and prevent the other afflictions associated with current therapies, namely, thrombosis and neointimal hyperplasia. Therefore, the goal of this study was to study the efficacy of a bioinspired multifunctional nanomatrix in recruiting and promoting the

Read More 

Moon et al., Int J Cardiol, 2012

Human pluripotent stem cells (hPSCs) hold great promise for treating ischemic heart disease. However, current protocols for differentiating hPSCs either result in low yields or require expensive cytokines. Here we developed a novel two dimensional (2D) stepwise differentiation system that generates a high yield of cardiomyocytes (CMs) from hPSCs without using special cytokines. Initially, undifferentiated hPSCs were transferred onto Matrigel-coated plates without forming embryoid bodies (EBs) for a few days and were cultured in bFGF-depleted human embryonic stem cells (hESCs) medium. When linear cell aggregation

Read More 

Sohn et al., Prog Mol Biol Transl Sci, 2012

The technology for generation of induced pluripotent stem cell (iPSC) from somatic cells emerged to circumvent the ethical and immunological limitations of embryonic stem cell (ESC). The recent progress of iPSC technology offers an unprecedented tool for regenerative medicine; however, integrating viral-driven iPSCs prohibits clinical applications by their genetic alterations and tumorigenicity. Various approaches including nonintegrating, nonviral, and nongenetic methods have been developed for generating clinically compatible iPSCs. In addition, approaches for using more clinically convenient or compatible source

Read More